Two doses of Pfizer and AstraZeneca do not generate satisfactory micron response, study finds

Two doses of Pfizer and AstraZeneca do not generate satisfactory micron response, study finds" title="Two doses of Pfizer and AstraZeneca do not generate satisfactory micron response, study finds" />

A group of researchers from the University of Oxford, in the United Kingdom, conducted a study to determine how effective the Oxford/AstraZeneca and Pfizer/BioNTech vaccines are in stimulating the production of neutralizing antibodies against Omicron, a variant of coronavirus identified a few months ago and had new cases identified in Brazil.

The research revealed that immunization with two doses of both AstraZeneca and Pfizer fail to generate a satisfactory immune response against the Omicron variant, that is, they induce little production of neutralizing antibodies that act to prevent the virus from being able to bind to human cells and force its reproduction in the organism.

As the study explains, the experiment used blood samples from several people who received complete immunization with the respective vaccines and relied on the Com-VOC method on a live virus of the new strain. It was identified during the research that the antibody rate remained below detectable in most participants, except for one.

According to the scientists, in the Pfizer/BioNTech immunizer the fall in the production of neutralizing antibodies was 29.8%, a number that worries researchers about the possibility of a new wave of contagion propagated by the Omicron variant of Sars-Cov-2.

The study did not count on the participation of any person vaccinated with the booster dose, because of this, it is not possible to assume the amount of neutralizing antibodies generated in those who received three applications, but the researchers are optimistic about the response generated in the body with the additional dose.

This data will help those developing vaccines and vaccination strategies determine routes to best protect their populations and convey the message that those who are eligible for a booster should get it.”

Gavin Screaton,

Head of the Division of Medical Sciences at the University and lead author of the article.

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